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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Related Experiment Video

Updated: Jun 10, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
08:07

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

Yeast proteomics and protein microarrays.

Rui Chen1, Michael Snyder

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

Journal of Proteomics
|August 24, 2010
PubMed
Summary
This summary is machine-generated.

Protein microarray technology revolutionizes yeast research, enabling large-scale studies of biological networks. This advances understanding of fundamental life processes and human diseases.

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Identification of protein complexes with quantitative proteomics in S. cerevisiae
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Identification of protein complexes with quantitative proteomics in S. cerevisiae

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Microarray Analysis for Saccharomyces cerevisiae
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Microarray Analysis for Saccharomyces cerevisiae

Published on: April 7, 2011

Related Experiment Videos

Last Updated: Jun 10, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
08:07

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

Published on: August 2, 2015

Identification of protein complexes with quantitative proteomics in S. cerevisiae
11:12

Identification of protein complexes with quantitative proteomics in S. cerevisiae

Published on: March 4, 2009

Microarray Analysis for Saccharomyces cerevisiae
13:17

Microarray Analysis for Saccharomyces cerevisiae

Published on: April 7, 2011

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Proteomics

Background:

  • Yeast (Saccharomyces cerevisiae) is a crucial model organism for understanding biological processes and human diseases due to its simple genome and conserved mechanisms.
  • Systems biology and proteomic studies in yeast were historically challenging.
  • Advancements in high-throughput technologies have overcome previous limitations.

Purpose of the Study:

  • To highlight the impact of protein microarray technology on yeast research.
  • To showcase how this technology facilitates large-scale network interrogation.
  • To emphasize the potential for understanding biological phenomena and diseases.

Main Methods:

  • Development and application of high-throughput protein microarray technology in yeast.
  • Interrogation of protein-protein, protein-DNA, and protein-small molecule interactions.
  • Analysis of post-translational modification networks on a large scale.

Main Results:

  • Protein microarray technology enables high-throughput analysis of complex biological networks in yeast.
  • Groundbreaking findings have been achieved that were not possible with traditional methods.
  • Discovery of these networks provides a proteomic perspective on biological processes.

Conclusions:

  • Protein microarray technology is a powerful tool for yeast systems biology and proteomics.
  • This technology significantly enhances our understanding of fundamental biological mechanisms.
  • Findings from yeast research using protein microarrays have implications for human health and disease.