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Updated: Jun 10, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Irreversible blindness in juvenile systemic lupus erythematosus
R T Almeida1, N E Aikawa, A M E Sallum
1Pediatric Rheumatology Unit, Children's Hospital, Hospital das Clínicas da Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil.
Lupus
|August 24, 2010
Summary
Severe vision loss from vasculitis or uveitis is rare in juvenile systemic lupus erythematosus (JSLE). This study highlights two cases of irreversible blindness in JSLE patients due to these conditions.
Area of Science:
- Ophthalmology
- Rheumatology
- Pediatrics
Background:
- Juvenile systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting children.
- Ocular complications, including blindness, are infrequent but severe manifestations of JSLE.
Observation:
- This study reviewed 5367 patients over 27 years, identifying 263 with JSLE.
- Two (0.8%) JSLE patients experienced irreversible blindness due to ocular vasculitis and uveitis.
Findings:
- One patient presented with cutaneous vasculitis, iridocyclitis, and retinal vasculitis.
- Another developed blindness secondary to varicella zoster virus-associated necrotizing vasculitis after immunosuppressive therapy.
Implications:
- Blindness from retinal vasculitis/uveitis is a rare, severe JSLE complication.
- Ocular involvement in JSLE necessitates vigilant monitoring, especially with disease activity or viral infections.
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