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Related Experiment Video

Updated: Jun 10, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Immune cell location and function during post-natal mammary gland development.

Johanna R Reed¹, Kathryn L Schwertfeger

¹Department of Lab Medicine and Pathology, Graduate Program in Microbiology, Immunology and Cancer Biology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

Journal of Mammary Gland Biology and Neoplasia

|August 24, 2010

Summary

Immune cells are crucial for post-natal mammary gland development. This review details immune cell localization, recruitment, and functional roles in mammary gland development.

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Area of Science:

Developmental Biology
Immunology
Cell Biology

Background:

Post-natal mammary gland development involves intricate epithelial-stromal cell interactions.
Immune cells and their mediators play a significant role throughout mammary gland development stages.
The precise functional contributions of immune cells to mammary gland development are not fully elucidated.

Purpose of the Study:

To review the localization of immune cells within the mammary gland during post-natal development.
To summarize mechanisms of immune cell recruitment to the mammary gland.
To outline the functional roles of immune cells in mammary gland development.

Main Methods:

Literature review of recent studies on mammary gland development and immunology.
Analysis of immune cell localization patterns at different developmental stages.
Synthesis of research on immune cell recruitment and function.

Main Results:

Immune cells are present in specific locations within the mammary gland during post-natal development.
Mechanisms governing immune cell recruitment involve various signaling pathways.
Immune cells exert diverse functional effects on mammary gland development.

Conclusions:

Immune cell localization, recruitment, and function are critical for successful mammary gland development.
Further research is needed to fully understand the complex interplay between immune cells and mammary gland development.