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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: Jun 10, 2026

Expansion and Enrichment of Gamma-Delta (γδ) T Cells from Apheresed Human Product

Expansion and Enrichment of Gamma-Delta (γδ) T Cells from Apheresed Human Product

Published on: September 22, 2021

[Research progress of gammadelta T cell-based immunotherapy].

Fu-ming Qiu¹, Zhong-peng Li, Jian Huang

¹Department of Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences

|August 24, 2010

Summary

GammadeltaT cells, particularly Vgamma9Vdelta2T cells, offer a promising avenue for cancer immunotherapy by recognizing tumor antigens without MHC restriction. Their demonstrated anticancer activity and positive clinical trial results highlight their therapeutic potential.

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Area of Science:

Immunology
Cell Biology
Oncology

Context:

GammadeltaT cells bridge innate and adaptive immunity, recognizing antigens independently of MHC.
Vgamma9Vdelta2T cells, a subset found in peripheral blood and tumors, are activated by phosphoantigens.
These cells proliferate with IL-2 stimulation and exhibit cytotoxic effects against various cancer types.

Purpose:

To review recent advancements in understanding gammadeltaT cell antigen recognition and activation.
To explore the application of gammadeltaT cell-based immunotherapies for cancer treatment.

Summary:

Vgamma9Vdelta2T cells demonstrate in vitro anticancer activity and in vivo tumor growth inhibition (lymphoma, breast cancer, melanoma).
Phase I clinical trials involving Vgamma9Vdelta2T cell therapy for lung, renal, and prostate cancers have yielded encouraging outcomes.
This review synthesizes current knowledge on gammadeltaT cell mechanisms and their therapeutic potential in oncology.

Impact:

Highlights the potential of gammadeltaT cells as a novel immunotherapy for diverse cancers.
Provides insights into the mechanisms of Vgamma9Vdelta2T cell activation and anti-tumor function.
Supports the ongoing development of gammadeltaT cell-based cancer treatments.