Related Experiment Video

Updated: Jun 10, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

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[Dual role of transcription factor AP-2 in carcinogenesis]

Shuo Liang1, Hong Deng

  • 1Department of Pathology, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|August 24, 2010
PubMed

Insights

Activating protein-2 (AP-2) transcription factors regulate cell processes and their role in cancer is complex, acting as either tumor suppressors or promoters. This review explores AP-2

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Context:

  • Activating protein-2 (AP-2) is a family of transcription factors regulating cell functions.
  • Five isoforms (AP-2alpha, -beta, -gamma, -delta, -epsilon) exist.
  • AP-2 proteins are crucial in cell proliferation, differentiation, apoptosis, and embryogenesis.

Purpose:

  • To review the recent advancements in understanding the role of AP-2 in oncogenesis.
  • To discuss the dual function of AP-2 in tumorigenesis.
  • To highlight potential clinical applications of AP-2 research.

Summary:

  • AP-2 transcription factors play a significant role in cancer development.
  • Their function in tumorigenesis can be inhibitory or promoting, depending on context.
  • This duality is influenced by tissue type, cancer stage, and specific AP-2 isoform.

Impact:

  • Provides insights into the complex mechanisms of cancer development.
  • Identifies AP-2 as a potential target for cancer therapy.
  • Informs future clinical strategies for cancer treatment and diagnosis.

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