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Updated: Jun 10, 2026
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Outpatient parenteral antimicrobial therapy today
Joseph A Paladino1, Donald Poretz
1Clinical Outcomes Research, CPL Associates, Amherst, New York, USA.
Summary
Outpatient parenteral antimicrobial therapy (OPAT) is a safe and effective treatment for long-term infections. A comprehensive pharmacoeconomic analysis of OPAT, considering clinical outcomes, is needed.
Area of Science:
- Infectious Diseases
- Pharmacoeconomics
- Health Services Research
Background:
- Outpatient parenteral antimicrobial therapy (OPAT) has been a standard treatment for infections requiring long-term intravenous antibiotics since the 1970s.
- OPAT is delivered in various settings, including homes, physician offices, clinics, and infusion centers, with increasing self-administration by patients.
- Patient selection for OPAT is based on infection course, suitability for outpatient care, and reimbursement availability, with reported safety, efficacy, practicality, and cost-effectiveness.
Purpose of the Study:
- To conduct a comprehensive, clinical outcomes-based pharmacoeconomic analysis of outpatient parenteral antimicrobial therapy (OPAT).
- To address the gap in existing literature regarding the economic impact of OPAT when analyzed through the lens of clinical outcomes.
Main Methods:
- Utilizing data from the OPAT Outcomes Registry, which includes information on over 11,000 antibiotic courses administered between 1997 and 2000.
- Performing a pharmacoeconomic analysis that integrates clinical outcomes with economic data.
Main Results:
- The OPAT Outcomes Registry provides a substantial dataset for analysis.
- Existing studies on OPAT's economic impact often lack a comprehensive, clinical outcomes-based approach.
Conclusions:
- A comprehensive, clinical outcomes-based pharmacoeconomic analysis of OPAT is currently lacking in the literature.
- Further research is warranted to fully understand the economic value of OPAT in relation to patient health outcomes.
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