Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contribution of HMGB1 to keratinocyte inflammation in recessive dystrophic epidermolysis bullosa.

JID innovations : skin science from molecules to population health·2026
Same author

ATGL-catalyzed lipid catabolism promotes DNA repair.

bioRxiv : the preprint server for biology·2026
Same author

Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.

Cell reports·2026
Same author

SETDB1/ATF7IP regulate the precise genome engineering of HUSH-regulated genes.

Epigenetics & chromatin·2026
Same author

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators.

ACS chemical biology·2026
Same author

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators.

bioRxiv : the preprint server for biology·2025
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

HDM2 ERKs PCNA.

Hai Dang Nguyen1, Anja-Katrin Bielinsky

  • 1Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

The Journal of Cell Biology
|August 25, 2010
PubMed
Summary
This summary is machine-generated.

The study reveals how the kinase ERK8 regulates proliferating cell nuclear antigen (PCNA) turnover. Inactivating ERK8 leads to genome instability and cell transformation, highlighting its crucial role in maintaining genomic integrity.

More Related Videos

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
08:01

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
08:01

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Proliferating cell nuclear antigen (PCNA) is a crucial protein involved in DNA replication and repair.
  • The regulation of PCNA turnover is essential for maintaining genomic stability.
  • Extracellular signal-regulated kinase 8 (ERK8) is a kinase with known roles in cellular processes.

Purpose of the Study:

  • To investigate the role of ERK8 in the regulation of PCNA turnover.
  • To understand the consequences of ERK8 inactivation on genome stability and cell transformation.

Main Methods:

  • The study likely involved molecular biology techniques to assess PCNA levels and turnover.
  • Experiments were performed to analyze the effects of ERK8 inactivation on cellular processes.
  • Genome instability and cell transformation assays were likely employed.

Main Results:

  • ERK8 was found to counteract the turnover of proliferating cell nuclear antigen (PCNA).
  • Inactivation of ERK8 led to significant genome instability.
  • Loss of ERK8 function was associated with the transformation of cells.

Conclusions:

  • ERK8 plays a critical role in regulating PCNA turnover, thereby maintaining genome stability.
  • Disruption of ERK8 function has severe consequences, including genome instability and cell transformation.
  • ERK8 represents a potential target for understanding and potentially treating diseases associated with genomic instability.