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Syntheses, structural characterization and CO releasing properties of boranocarbonate [H3BCO2H]- derivatives
Tamil Selvi Pitchumony1, Bernhard Spingler, Roberto Motterlini
1University of Zürich, Institute of Inorganic Chemistry, Winterthurerstr. 190, 8057, Zürich, Switzerland.
Abstract:
CO plays an important role in biological processes and molecules which release CO in a controllable way could therefore be used for medicinal purposes. Beside organometallic carbonyl complexes, boranocarbonate [H(3)BCO(2)H](-) is one of the most promising candidates but releases CO too rapidly. In order to delay the CO release, we have prepared boranocarbamates [H(3)BCONH-R](-) from [H(3)BCO(2)H](-) which comprise histamine, morpholine, aniline and ethylene-diamine bound via amides to the {H(3)BCO} moiety. The syntheses of the new derivatives is described together with their structural characterization. These compounds release CO at a much slower rate than the parent compound and are therefore potential CO releasing molecules for biological and medicinal application.
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