Sequential cascade of pyranose 2-oxidase and sodium tungstate for selective sulfoxidation of thioethers
Yihong Wang1, Dong Liu1, Hao Wu1
1School of Pharmaceutical Sciences and Institute of Materia Medical, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission (Shandong Academy of Medical Sciences), Key Lab for Rare and Uncommon Diseases of Shandong Province, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China. baizhushuang@163.com.
Abstract:
Sulfoxides, as essential structural scaffolds, are commonly found in pharmaceuticals and bulk chemicals. We report a practical enzymatic approach for the selective oxidation of thioethers to sulfoxides. Under an oxygen atmosphere, using D-glucose as the substrate and flavin adenine dinucleotide (FAD) as a cofactor, this system relies on the sequential cascade of pyranose 2-oxidase (P2OX) and sodium tungstate dihydrate (Na2WO4·2H2O) to accomplish selective thioether oxidation under mild and environmentally friendly conditions. It provides a sustainable, robust and operationally simple route for sulfoxide synthesis.
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