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Updated: Jun 9, 2026
Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
Published on: November 29, 2019
Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis
Karine Le Roux1, Laurent Kodjikian, Romain Marignier
1Department of Internal Medicine, Hôtel Dieu, Hospices Civils de Lyon, and University Claude Bernard Lyon 1, Lyon, France.
Purpose:
To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU).
Methods:
Retrospective study of 17 patients with unexplained IU. All the patients underwent physical examination, complete laboratory tests, and cerebrospinal MRI.
Results:
Out of the 12 patients who underwent a lumbar puncture, six had oligoclonal bands and/or increased IgG index.
Conclusion:
Intrathecal synthesis of immunoglobulins is not rare in patients with unexplained IU. A longer follow-up is mandatory to determine whether intrathecal immunoglobulins synthesis has a predictive value for subsequent progression to multiple sclerosis.
