[The expression of BAG-1 and its clinical significance in human lung cancer.]
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Published on: January 3, 2013
Hongyu Liu1, Yun Bai, Baoxing Liu
1Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Anshan Road No.154, Heping District, Tianjin 300052, China.
Background:
BAG-1 is a multifunctional anti-apoptotic protein that binds to a variety of cellular proteins and affects their functions. It has been proven that overexpression of BAG-1 was observed in a number of human maligancies and correlated with their prognosis. The aim of this study is to determine BAG-1 mRNA expression in human lung cancer tissues and its clinical significance.
Methods:
The expression of BAG-1 was detected by real-time PCR in formalin-fixed, paraffin-embedded human lung cancer tissues of 156 cases.
Results:
(1) The median survival time (MST, 33.5 months) in BAG-1 low-expression group was significantly higher than that (20.5 months) in BAG-1 highexpression group (P <0.005); (2) The 3-year and 5-year survival rates (44.74%; 26.32%) in BAG-1 low-expression group were dramatically higher than that in BAG-1 high-expression group (32.5%; 21.25%)(P <0.05), respectively. The survival curves in BAG-1 low-expression group was also significantly better than that in BAG-1 high-expression group (P =0.045); (3) The further analysis indicated that the survical curves in BAG-1 low-expression group were much better than that in BAG-1 high-expression group in the lung cancer patient with TNM stage I, or with squamous cell cacrinoma, or without any metastasis, respectively (P <0.05).
Conclusions:
BAG-1 may be a biomarker for the prognosis of lung cancer patients, especially for the lung cancer patients with stage I or squamous cell carcinoma.
