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Updated: Jun 9, 2026
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
[Relationship between Glut-1, Glut-3 expression and fluorodeoxyglucose uptake in NSCLC and benign pulmonary lesion.]
Tao Wu1, Tiecheng Pan, Zhi Zheng
1Department of Cardiac and Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan 430030, China.
Background:
It has been known that facilitative glucose transporter (GLUT) is the main carrier which intervenes the glucose uptake of cell. The expression of Glut-1, Glut-3 has close relationship with the uptake of (18)Fluoro-2-deoxyglucose (FDG). The aim of this study is to discuss the relationship between expression of glucose transporter-1, 3 (Glut-1, Glut-3) and FDG uptake in NSCLC and benign pulmonary lesion.
Methods:
Eighty-four NSCLC patients and twenty-four benign pulmonary lesion patients received PET/CT scan before operation. The expression of Glut-1, Glut-3 was detected by immunohistochemistry. The relationship among these factors was investigated.
Results:
The range of average SUV (SUVave) of the eighty-four patients was 3.6-13.2, and the average value was 7.8+/-3.0. The range of average SUV (SUVave) of the twenty-four patients was 1.2-9.2, and the average value was 3.2+/-1.9. In NSCLC tissues, the average immunohistochemical staining intensity of Glut-1, Glut-3 was 4.4+/-1.3 and 2.6+/-1.9, respectively. In benign pulmonary lesion, the average immunohistochemical staining intensity of Glut-1, Glut-3 was 0.9+/-0.9 and 1.2+/-1.4, respectively. Both of the Glut-1 and the Glut-3 expression levels were significantly higher in NSCLC than those in benign pulmonary lesion (P <0.01). Glut-1 expression was positively correlated to SUVave (r =0.78, P <0.01) in NSCLC patients. Glut-3 expression was positively correlated to SUVave (r =0.45, P =0.03) in benign pulmonary lesion patients.
Conclusions:
The results show Glut-1 and Glut-3 express not only in NSCLC but also in benign pulmonary lesion. Glut-1 play an important role in FDG uptake in NSCLC. Glut-3 play an important role in FDG uptake in benign pulmonary lesion.
