Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

A fillable micro-hollow sphere lesion detection phantom using superposition.

Frank P Difilippo¹, Sven L Gallo, Ryan S Klatte

¹Department of Nuclear Medicine, Imaging Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Physics in Medicine and Biology

|August 26, 2010

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bilateral Modified Self-Expanding Valve Implantation in Branch Pulmonary Arteries.

JACC. Case reports·2026

Same author

Particle Therapy Co-Operative Group Consensus Statement on Reirradiation With Proton Therapy for Prostate Cancer.

International journal of particle therapy·2026

Same author

Pseudohypobicarbonatemia: Discordant Bicarbonate Values in Serum and Arterial Samples.

Journal of Brown hospital medicine·2026

Same author

Fatigue performance of additively manufactured porous titanium for orthopaedic applications.

Journal of the mechanical behavior of biomedical materials·2026

Same author

Desmoplastic Small Round Blue Cell Tumor in a Young Adult Man: A Rare Case of Abdominal Sarcoma.

The American journal of case reports·2026

Same author

Treat-to-Target in Inflammatory Bowel Diseases: Lessons from Screening in a Pragmatic Clinical Trial.

Crohn's & colitis 360·2026

This study introduces a novel micro-hollow sphere phantom for evaluating small-animal SPECT and PET scanners. The new phantom overcomes limitations of existing phantoms, enabling accurate lesion detection assessment for small scanners.

Area of Science:

Medical Imaging
Nuclear Medicine
Small Animal Imaging

Background:

Traditional phantoms for SPECT and PET lesion detection have limitations for small-animal scanners, including wall effects and fabrication difficulties for small spheres.
Accurate performance evaluation of small-animal SPECT and PET scanners is crucial for advancing preclinical research.

Purpose of the Study:

To develop and validate a micro-hollow sphere phantom that overcomes the limitations of existing phantoms for small-animal SPECT and PET scanners.
To enable accurate assessment of lesion detection performance in small-animal imaging.

Main Methods:

A novel micro-hollow sphere phantom was fabricated using stereolithography, featuring interchangeable sectors with hollow spheres (1-14 microL).
The phantom utilizes a superposition principle with internal rotation to acquire separate sphere and background counts, eliminating the wall effect.

More Related Videos

A Stable Phantom Material for Optical and Acoustic Imaging

A Stable Phantom Material for Optical and Acoustic Imaging

Published on: June 16, 2023

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

Published on: October 5, 2018

Related Experiment Videos

Last Updated: Jun 9, 2026

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

A Stable Phantom Material for Optical and Acoustic Imaging

A Stable Phantom Material for Optical and Acoustic Imaging

Published on: June 16, 2023

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

Published on: October 5, 2018

Raw data were subsampled and reconstructed to generate images at various contrast ratios for lesion detection threshold determination.

Main Results:

The micro-hollow sphere phantom successfully eliminated the wall effect, a significant source of error in previous phantoms.
Lesion detection thresholds were determined for a SPECT/CT scanner, showing a 4:1 ratio for 1.5 mm spheres and 3:1 ratio for 2.0 mm spheres.
The phantom demonstrated practical utility and suitability for comparing the task-based performance of small-animal SPECT and PET scanners.

Conclusions:

The developed micro-hollow sphere phantom is a practical and effective tool for evaluating lesion detection performance in small-animal SPECT and PET imaging.
This phantom addresses key limitations of existing methods, paving the way for more accurate scanner comparisons and improved preclinical imaging research.