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Related Experiment Video

Updated: Jun 9, 2026

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Sphingolipids in neurodegeneration.

Norman J Haughey¹

¹Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6-109, 600 North Wolfe Street, Baltimore, MD 21287, USA. nhaughe1@jhmi.edu

Neuromolecular Medicine

|August 26, 2010

Summary

This summary is machine-generated.

Sphingolipids are crucial for brain function and signaling. Research is advancing our understanding of how sphingolipid metabolism impacts neurodegenerative diseases like Alzheimer's and Multiple Sclerosis.

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Last Updated: Jun 9, 2026

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Area of Science:

Neuroscience
Molecular Biology
Biochemistry

Background:

Sphingolipids are abundant in the brain, but their roles in neural function are not fully understood.
Previously considered structural components, many sphingolipids are now recognized as active signaling molecules.
Advances in technology are enhancing the study of sphingolipids in neural regulation.

Purpose of the Study:

To review emerging technologies for sphingolipid analysis.
To explore sphingolipid metabolic pathways.
To examine the role of sphingolipid dysfunction in neurodegeneration.

Main Methods:

Review of current literature and technological advancements.
Analysis of sphingolipid metabolism and signaling pathways.
Examination of sphingolipid involvement in neurodegenerative disease pathogenesis.

Main Results:

New technologies facilitate detailed sphingolipid analysis.
Sphingolipid metabolism is critical for normal neural activity.
Dysfunctional sphingolipid metabolism is implicated in neurodegenerative disorders.

Conclusions:

Sphingolipids play active roles in neural signaling and function.
Understanding sphingolipid metabolism is key to addressing neurodegenerative diseases.
This special issue highlights advancements in sphingolipid research for neurological health.