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Updated: Jun 9, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
[Endothelial dysfunction in urolithiasis patients]
Urologiia (Moscow, Russia : 1999)
|August 26, 2010
Summary
Nephrolithiasis surgery can cause endothelial dysfunction, indicated by elevated ET-1, IL-6, and VEGF markers. Full recovery of endothelial function is not observed one month post-surgery.
Area of Science:
- Nephrology
- Vascular Biology
- Urology
Context:
- Nephrolithiasis (kidney stones) affects a significant portion of the population.
- Surgical interventions are common for treating kidney stones.
- Endothelial dysfunction is a known complication in various medical conditions.
Purpose:
- To investigate endothelial dysfunction in patients undergoing surgery for nephrolithiasis.
- To assess the levels of nitric oxide (NO), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and interleukin-6 (IL-6) in blood serum.
- To measure urinary NO and use beta-2 microglobulin as an indicator of tubular dysfunction.
Summary:
- Patients with nephrolithiasis exhibited elevated serum concentrations of ET-1, IL-6, and VEGF, indicating endothelial dysfunction.
- This dysfunction was particularly pronounced in the early postoperative period following short-wave lithotripsy.
- One month after surgery (open surgery or lithotripsy), complete recovery of endothelial function was not achieved.
Impact:
- Highlights the persistent impact of nephrolithiasis surgery on vascular health.
- Suggests the need for monitoring and potential interventions to manage endothelial dysfunction post-surgery.
- Provides insights into the differential effects of surgical methods on endothelial recovery.
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