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Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

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Related Experiment Video

Updated: Jun 9, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

[Hypercoagulability and ischemic stroke in young patients].

M Martínez-Martínez1, R Cazorla-García, L A Rodríguez de Antonio

  • 1Servicio de Neurología, Centro de Ictus, Hospital Universitario La Paz, IdiPaz, Renevas, Universidad Autónoma de Madrid, Madrid, España.

Neurologia (Barcelona, Spain)
|August 27, 2010
PubMed
Summary

Hypercoagulable states are common in young adults experiencing ischemic stroke, affecting nearly half of patients. These prothrombotic abnormalities, including hyperhomocysteinemia and factor V Leiden, are frequent in this demographic.

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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Area of Science:

  • Neurology
  • Hematology
  • Genetics

Context:

  • Cerebral venous thrombosis is linked to hypercoagulable states.
  • Arterial ischemic stroke in young patients may also be influenced by these conditions.
  • Understanding these risk factors is crucial for effective management and prevention strategies.

Purpose:

  • To investigate the prevalence of prothrombotic abnormalities in young patients with ischemic stroke.
  • To identify specific hypercoagulable states common in this patient group.
  • To explore potential associations between these states and stroke characteristics or outcomes.

Summary:

  • A study of 100 patients under 55 with ischemic stroke found that 46% had a hypercoagulable state.
  • Acquired hyperhomocysteinemia (18%) was the most frequent abnormality, followed by protein C or S deficiency (8%) and factor V Leiden mutation (5%).
  • No significant association was found with stroke severity or outcomes, but a trend emerged for atherothrombotic stroke.

Impact:

  • Highlights the high frequency of hypercoagulable states in young ischemic stroke patients.
  • Suggests that screening for prothrombotic abnormalities may be warranted in this population.
  • Informs therapeutic management and secondary prevention approaches for young stroke survivors.