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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Oxidative stress, systemic inflammation, and severe periodontitis
F D'Aiuto1, L Nibali, M Parkar
1Periodontology Unit, Division of Clinical Research, UCL Eastman Dental Institute and Hospital, 256 Gray's Inn Road, London WC1X 8LD, UK. f.daiuto@eastman.ucl.ac.uk
Journal of Dental Research
|August 27, 2010
Summary
Severe periodontitis is linked to increased oxidative stress, indicated by higher reactive oxygen metabolites (D-ROM) and lower antioxidant capacity. Periodontal treatment temporarily elevates D-ROM levels.
Area of Science:
- Biomedical Science
- Oral Health Research
- Inflammation and Oxidative Stress Studies
Background:
- Periodontal infections are linked to chronic inflammation.
- Oxidative stress plays a role in inflammatory conditions.
- The relationship between severe periodontitis and oxidative stress requires further investigation.
Purpose of the Study:
- To investigate the association between severe periodontitis and oxidative stress.
- To evaluate the impact of periodontal therapy on oxidative stress markers.
Main Methods:
- A case-control study involving 145 periodontitis patients and 56 controls.
- A pilot intervention study with 14 periodontitis patients undergoing therapy.
- Measurement of serum diacron-reactive oxygen metabolites (D-ROM), antioxidant potential, C-reactive protein (CRP), interleukin-6, and lipid profiles.
Main Results:
- Severe periodontitis patients showed significantly higher D-ROM levels and lower antioxidant capacity compared to controls.
- D-ROM levels correlated positively with CRP and clinical periodontal parameters.
- Periodontal therapy led to acute increases in D-ROM levels.
Conclusions:
- Severe periodontitis is positively associated with oxidative stress.
- Oxidative stress markers are elevated in patients with severe periodontitis.
- Periodontal therapy temporarily increases oxidative stress markers.
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