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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis and Cardiovascular Diseases. Consensus Report
M Sanz1, A Marco Del Castillo2, S Jepsen3
1Department of Dental Clinical Specialties and ETEP Research Group, Faculty of Odontology, University Complutense of Madrid, Plaza Ramon y Cajal, Madrid, ES.
Insights
Severe periodontitis is linked to cardiovascular disease (CVD), a major cause of death in Europe. This review updates evidence on the periodontitis-CVD association, its mechanisms, and treatment impacts.
Area of Science:
- Periodontology
- Cardiology
- Public Health
Background:
- Cardiovascular disease (CVD) causes 45% of deaths in Europe, with ischemic heart disease, stroke, and hypertension as primary drivers.
- Periodontitis, a prevalent chronic non-communicable disease (NCD), particularly severe periodontitis affecting 11.2% globally, is the sixth most common human disease.
Purpose of the Study:
- To update epidemiological evidence on the association between periodontitis and CVD.
- To review mechanistic links between periodontitis and CVD.
- To assess the impact of periodontal therapy on cardiovascular outcomes and patient safety.
Main Methods:
- Review of scientific literature and proceedings from a joint workshop by the European Federation of Periodontology (EFP) and World Heart Federation (WHF).
- Analysis of emerging scientific information from the past five years.
- Focus on potential risks and complications of periodontal therapy in patients on anti-thrombotic therapy.
Main Results:
- Significant associations between periodontitis and CVD are supported by updated epidemiological evidence.
- Mechanistic links and the impact of periodontal therapy on cardiovascular and surrogate outcomes have been evaluated.
- Potential risks associated with periodontal therapy in patients on anti-thrombotic medication were identified.
Conclusions:
- The review provides updated evidence on the periodontitis-CVD link, emphasizing the need for interdisciplinary collaboration.
- Recommendations are provided for dentists, physicians, and patients regarding managing periodontitis in the context of CVD.
- Understanding these associations is crucial for public health strategies aimed at reducing NCD burden.
Background:
In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to heart failure) the major cause of these CVD related deaths. Periodontitis is also a chronic non-communicable disease (NCD) with a high prevalence, being severe periodontitis, affecting 11.2% of the world's population, the sixth most common human disease.
Material And Methods:
There is now a significant body of evidence to support independent associations between severe periodontitis and several NCDs, in particular CVD. In 2012 a joint workshop was held between the European Federation of Periodontology (EFP) and the American Academy of Periodontology to review the literature relating periodontitis and systemic diseases, including CVD. In the last five years important new scientific information has emerged providing important emerging evidence to support these associations.
Results And Conclusions:
The present review reports the proceedings of the workshop jointly organised by the EFP and the World Heart Federation (WHF), which has updated the existing epidemiological evidence for significant associations between periodontitis and CVD, the mechanistic links and the impact of periodontal therapy on cardiovascular and surrogate outcomes. This review has also focused on the potential risk and complications of periodontal therapy in patients on anti thrombotic therapy and has made recommendations for dentists, physicians and for patients visiting both the dental and medical practices.
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