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Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

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Aerobic exercise training-induced decrease in plasma visfatin and insulin resistance in obese female adolescents.

Kyu-Jin Lee¹, Yun-A Shin, Kyoung-Young Lee

¹Institute of Sports Science, Seoul National University, Seoul, Korea.

International Journal of Sport Nutrition and Exercise Metabolism

|August 27, 2010

Summary

Aerobic exercise significantly lowered plasma visfatin and insulin resistance in obese adolescent females. This 12-week program demonstrated that regular physical activity is key for improving metabolic health in this demographic.

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Area of Science:

Endocrinology
Exercise Physiology
Pediatric Obesity

Background:

Visfatin, an adipokine, plays a role in metabolic regulation.
Obesity in adolescent females is linked to elevated visfatin and insulin resistance.

Purpose of the Study:

To compare plasma visfatin levels between normal-weight and obese adolescent females.
To evaluate the impact of a 12-week aerobic exercise program on plasma visfatin and insulin resistance in obese adolescent females.

Main Methods:

A comparative study involving 20 normal-weight and 18 obese female adolescents.
The obese group was divided into an exercise group (12 weeks, 4-5 sessions/week, 300-400 kcal/day expenditure) and a control group.
Plasma visfatin levels and insulin resistance were measured before and after the intervention.

Main Results:

Obese females exhibited significantly higher plasma visfatin levels compared to normal-weight females (p < .05).
The exercise group showed significant reductions in both plasma visfatin (294.00 ± 124.74 to 185.55 ± 67.30 ng/ml, p < .01) and insulin resistance (p < .05) after 12 weeks.
No significant changes were observed in the control group.

Conclusions:

Elevated plasma visfatin is associated with obesity in adolescent females.
A 12-week aerobic exercise program, expending 1200-1600 kcal/week, effectively reduces plasma visfatin and insulin resistance in obese adolescent females.
Aerobic exercise is a viable strategy for managing metabolic dysfunction in this population.