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Serum fructosamine and lipid profile in type I diabetic children in Turkey
1Biochemistry Department, Medical Faculty, Cukurova University, Adana, Turkey.
Insights
Children with Type I diabetes showed higher serum triglycerides and fructosamine levels compared to healthy children. Extremely high fructosamine values were noted in Turkish diabetic children, indicating potential differences in diabetes management or metabolic response.
Area of Science:
- Pediatric Endocrinology
- Clinical Biochemistry
- Diabetes Mellitus Research
Background:
- Type I diabetes in children can affect lipid metabolism and glycemic control.
- Fructosamine is a marker for glycemic control over the preceding 2-3 weeks.
- Lipoprotein cholesterol fractions are crucial indicators of cardiovascular risk.
Purpose of the Study:
- To compare lipid profiles and fructosamine levels in children with Type I diabetes versus healthy controls.
- To investigate potential differences in metabolic markers between diabetic and non-diabetic pediatric populations.
- To highlight unique findings regarding fructosamine levels in a specific demographic.
Main Methods:
- Serum samples were collected from 23 children with Type I diabetes and 20 healthy children (aged 4-14 years).
- Measurements included total cholesterol, triglycerides, HDL-C, LDL-C, and fructosamine.
- Statistical analysis was performed to compare mean values between the two groups.
Main Results:
- Mean serum triglycerides and fructosamine were significantly higher in diabetic children.
- No significant difference was observed in mean total cholesterol and HDL-C between groups.
- Extremely high fructosamine values were reported in Turkish diabetic children, a novel finding.
- LDL-C/HDL-C ratio was higher in diabetics, but the difference was not statistically significant.
Conclusions:
- Type I diabetes in children is associated with elevated triglycerides and fructosamine levels.
- Fructosamine may serve as a sensitive indicator of glycemic control in pediatric diabetes, with potential ethnic variations.
- Further research is needed to understand the implications of high fructosamine levels and the LDL-C/HDL-C ratio in pediatric diabetes.
Abstract:
Serum levels of total cholesterol (TC), triglycerides (TG), lipoprotein cholesterol fractions (HDL-C and LDL-C) and fructosamine (FA) were determined in twenty-three children with Type I diabetes and twenty healthy children aged 4-14 years. Mean serum TC and HDL-C did not differ significantly between diabetic and nondiabetic children. Mean serum TG and FA showed a statistically significant increase in the diabetic group compared to healthy children. It is interesting to note that extremely high FA values had never been reported in the literature before were obtained for the Turkish diabetic children. Although we have observed relatively higher values for LDL-C/HLD-C ratio in diabetics, the difference between two groups was not statistically significant.