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[Malacoplakia of the kidney].

Lj Dokić¹, D Cvetković, N Svirtlih

¹Institute of Infectious and Tropical Diseases, University Clinical Centre, Belgrade.

Srpski Arhiv Za Celokupno Lekarstvo

|May 1, 1990

Summary

Malakoplakia is a rare inflammatory condition resulting from defective macrophage function. This case highlights renal malakoplakia, diagnosed post-mortem via characteristic histopathology, including von Hansemann

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Area of Science:

Pathology
Immunology
Rare Diseases

Background:

Malakoplakia is an uncommon inflammatory disorder characterized by a unique host response to bacterial and fungal infections.
The condition stems from impaired macrophage (a type of white blood cell) function.
Histologically, malakoplakia infiltrates contain macrophages with characteristic intracytoplasmic inclusions known as Michaelis-Guttmann bodies.

Observation:

The authors report a case of renal malakoplakia in a 32-year-old female patient.
Clinical symptoms were nonspecific, hindering a definitive diagnosis during the patient's lifetime.
The diagnosis was confirmed post-mortem through autopsy and detailed histopathological examination.

Findings:

Histopathological analysis revealed the presence of von Hansemann's histiocytes (macrophages) and Michaelis-Guttmann bodies within the renal malakoplakia infiltrates.
These findings are pathognomonic for malakoplakia, confirming the diagnosis.

Implications:

This case underscores the diagnostic challenges posed by renal malakoplakia due to its often subtle and non-specific clinical presentation.
Autopsy and histopathology remain crucial for diagnosing rare conditions like malakoplakia, especially when clinical suspicion is low.
Understanding the pathognomonic histological features is vital for accurate diagnosis and contributes to the literature on rare inflammatory diseases.

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