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Identification of cis-3'-hydroxycotinine as a urinary nicotine metabolite

P Voncken¹, K Rustemeier, G Schepers

¹INBIFO Institut für biologische Forschung, Köln, FRG.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems

|December 1, 1990

Abstract:

1. cis-3'-Hydroxycotinine was detected as an S(-)-nicotine metabolite in the urine of smokers as well as in the urine of rats and hamsters dosed with nicotine. 2. The excreted amount of cis-3'-hydroxycotinine is lower than that of the trans-isomer.

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