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Updated: Aug 19, 2026
Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
[Evaluation of the efficacy of premedication using omega potential measurement]
Abstract:
Spontaneous and evoked omega-potentials were registered, using high-ohm amplifier of the permanent current and non-polarized liquid minute chlorine-silver electrodes, in 40 surgical patients 40-60 min after premedication. It has been established that effective premedication in 77% of cases (29 patients) correlated with low stable (variability 1-2 mV) values of omega-potential ranging from 0 to 20 mV and an omegagram in the form of a conventionally straight line in response to the functional load. In 11 patients with ineffective premedication the functional load caused phase, smooth or uneven changes in omega-potential (variability from 5 to 27 mV), with both low (0-20 mV) and intermediate (21-40 mV) initial values. Hexenal consumption was twice lower in patients with effective than in patients with ineffective premedication. It is concluded that omegametry can be used as an effective criterion in the assessment of premedication efficacy.
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