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Related Experiment Videos

Persistent light reactivity from systemic quinine.

C Guzzo1, K Kaidbey

  • 1Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia 19104.

Photodermatology, Photoimmunology & Photomedicine
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

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Oral quinine can cause persistent photosensitivity, even years after stopping the medication. This reaction, similar to persistent light reactors, highlights potential risks of quinine in phototherapy patients.

Area of Science:

  • Dermatology
  • Photobiology

Background:

  • Psoriasis patients undergoing phototherapy are susceptible to photosensitivity reactions.
  • Quinine is an antimalarial and muscle relaxant with known photosensitizing potential.

Observation:

  • A 41-year-old female with psoriasis experienced photosensitivity and Koebner phenomenon during phototherapy.
  • She was intermittently taking oral quinine for muscle cramps.
  • Photobiological testing showed a strong positive photopatch test to quinine sulfate.

Findings:

  • The patient exhibited a persistent reduction in minimal erythema dose to solar-simulated radiation.
  • No adverse reactions were noted with UVA exposure.
  • Photosensitivity persisted for over 3 years after quinine discontinuation.

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Implications:

  • Oral quinine can induce persistent photosensitivity, mimicking persistent light reactors.
  • Clinicians should consider quinine as a potential cause of photosensitivity in patients undergoing phototherapy.
  • Discontinuation of quinine may not always resolve photosensitivity promptly.