[Massive transfusion: methods and complications]

Massive blood transfusion is a therapeutic procedure increasingly common in anesthesiologic practice. In the present study we reviewed the literature on cellular changes and biochemical abnormalities developing in the blood components during storage. We also reviewed the different methods for infusion and the flow achieved depending on the type of intravenous catheter, infusion system, pressure methods, characteristics of the fluid, and type of filter. We also assessed the pathophysiology of the complications of massive blood transfusion: abnormalities of coagulation, metabolism, oxygen transportation, pulmonary function, hemodynamics and erythrocyte shape, plasma proteins denaturalization, toxicity of plastic products and hypoglycemia.