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Eosinophilic granuloma of lymph node. A case report
O Edamitsu1, S Sugihara, T Ohbuchi
1First Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
Acta Pathologica Japonica
|November 1, 1990
Summary
This case report details eosinophilic granuloma, a rare condition, localized to a lymph node in a young woman. Histological and ultrastructural analysis confirmed the diagnosis, with the patient showing no recurrence after 10 months.
Area of Science:
- Pathology
- Immunohistochemistry
- Electron Microscopy
Background:
- Eosinophilic granuloma is a rare disorder characterized by the proliferation of histiocytes.
- Localized forms, particularly in lymph nodes, are infrequently documented.
Observation:
- A 25-year-old Japanese woman presented with cervical lymphadenopathy and low-grade fever.
- Histological examination revealed distorted lymph node architecture with proliferation of histiocytoid cells, eosinophils, and multinucleated cells.
Findings:
- Ultrastructural analysis identified Birbeck granules in histiocytoid cells.
- Immunohistochemistry showed positivity for S-100 protein and negativity for lysozyme in the proliferating cells.
Implications:
- This case expands the understanding of eosinophilic granuloma's presentation in lymph nodes.
- The findings support the diagnosis of eosinophilic granuloma based on characteristic cellular morphology and markers.