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Effect of leu-(Asp, Asn, Glu, Gln) dipeptides on platelet aggregation in vitro
M Liakopoulou-Kyriakides1, G Stavropoulos, C Karagiannis
1Dept. of Chemical Engineering, Aristotelian University of Thessaloniki, Greece.
Biochemistry International
|November 1, 1990
Abstract:
A series of Leu-(Asp, Asn, Glu, Gln) dipeptides were synthesized and tested for their effect on human platelet aggregation in vitro induced by collagen, ADP, or adrenaline. It was found that only Leu-Asp-NH2 and Leu-Asn-NH2 inhibit rather strongly platelet aggregation, whereas a small inhibition was observed with Leu-Glu-NH2 and Leu-Gln-NH2, respectively.