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The worldwide problem of methicillin-resistant Staphylococcus aureus
W Brumfitt1, J M Hamilton-Miller
1Royal Free Hospital, School of Medicine, Hampstead, London, UK.
Drugs Under Experimental and Clinical Research
|January 1, 1990
Summary
Methicillin and aminoglycoside-resistant Staphylococcus aureus strains are a global hospital problem. Further research is needed for new antibiotics and control strategies against these difficult-to-treat infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Emergence of multidrug-resistant Staphylococcus aureus strains, specifically methicillin- and aminoglycoside-resistant strains, since the late 1970s.
- Global establishment of these resistant strains in hospital settings worldwide.
- Significant clinical and management challenges posed by outbreaks of infection and colonization.
Purpose of the Study:
- To address the limited therapeutic options for infections caused by methicillin- and aminoglycoside-resistant Staphylococcus aureus.
- To investigate challenges in clearing the carrier state of these resistant strains.
- To highlight the need for developing novel antibiotics and effective control measures.
Main Methods:
- Review of existing knowledge on the genetic and biochemical properties of resistant Staphylococcus aureus strains.
- Analysis of clinical and epidemiological data related to infections and colonization.
- Identification of research gaps in antibiotic development and control strategies.
Main Results:
- Established global prevalence of methicillin- and aminoglycoside-resistant Staphylococcus aureus.
- Demonstrated difficulties in treatment and carrier state eradication.
- Highlighted limitations in current therapeutic options.
Conclusions:
- Continued emergence and establishment of multidrug-resistant Staphylococcus aureus necessitate urgent attention.
- Further research is critical for developing new antimicrobial agents effective against these strains.
- Effective control strategies are required to manage the spread and impact of these infections in healthcare settings.