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Related Experiment Video

Updated: Jun 9, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Nephrotoxic lesions from 5-aminosalicylic Acid.

I C Calder, C C Funder, C R Green

British Medical Journal

|August 27, 2010

Summary

Single intravenous injection of 5-aminosalicylic acid caused kidney damage in rats. Renal papillary necrosis and cortical lesions occurred simultaneously, suggesting independent development in analgesic-associated kidney injury.

Area of Science:

Nephrology
Toxicology
Pharmacology

Background:

Analgesic abuse is linked to kidney damage, specifically renal papillary necrosis.
The pathogenesis of analgesic-induced nephropathy, particularly cortical lesions, remains incompletely understood.

Purpose of the Study:

To investigate the renal effects of 5-aminosalicylic acid (5-ASA) in a rat model.
To determine the relationship between cortical and papillary renal lesions induced by 5-ASA.

Main Methods:

Adult rats received a single intravenous injection of 5-aminosalicylic acid.
Renal tissues were examined for histological changes, focusing on proximal convoluted tubules and renal papilla.

Main Results:

5-Aminosalicylic acid induced necrosis in both the proximal convoluted tubules (cortical lesions) and the renal papilla.

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These two types of lesions developed concurrently.

Cortical lesions did not appear to be a secondary consequence of renal papillary necrosis.

Conclusions:

5-Aminosalicylic acid, structurally related to phenacetin and salicylates, can cause independent renal cortical and papillary damage.
These findings suggest that analgesic-induced nephropathy may involve independent development of cortical lesions, separate from renal papillary necrosis.
This highlights potential mechanisms underlying kidney damage from chronic analgesic misuse.