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Updated: Jun 9, 2026
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Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence
Lei Cui1, Ye Zhong, Weiping Zhu
1State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, China.
Chemical Communications (Cambridge, England)
|August 28, 2010
Abstract:
A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.
