Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intent matters: how flow and forms of information impact collective navigation.

Journal of the Royal Society, Interface·2023
Same author

Long-range seed dispersal enables almost stationary patterns in a model for dryland vegetation.

Journal of mathematical biology·2022
Same author

The impact of rheotaxis and flow on the aggregation of organisms.

Journal of the Royal Society, Interface·2021
Same author

Modelling collective navigation via non-local communication.

Journal of the Royal Society, Interface·2021
Same author

Spatial self-organisation enables species coexistence in a model for savanna ecosystems.

Journal of theoretical biology·2019
Same author

Modelling chase-and-run migration in heterogeneous populations.

Journal of mathematical biology·2019
Same journal

Effects of Seasonal Births and Predation on Disease Spread.

Bulletin of mathematical biology·2026
Same journal

Identifiability, Sensitivity, and Genetic Algorithms in Bacterial Biofilm Selection Models.

Bulletin of mathematical biology·2026
Same journal

Slow Evolution Towards Generalism in a Model of Variable Dietary Range.

Bulletin of mathematical biology·2026
Same journal

CBINN: Cancer Biology-Informed Neural Network for Unknown Parameter Estimation and Missing Physics Identification.

Bulletin of mathematical biology·2026
Same journal

A Cost-Sensitive Behavioral Modeling Analysis of the Early Identification and Control of Infectious Diseases.

Bulletin of mathematical biology·2026
Same journal

Tracking Dynamics of Superspreading Through Contacts, Exposures, and Transmissions in Edge-Based Network Epidemics.

Bulletin of mathematical biology·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads
07:52

In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads

Published on: November 26, 2019

How does cellular contact affect differentiation mediated pattern formation?

J M Bloomfield1, K J Painter, J A Sherratt

  • 1Department of Mathematics and the Maxwell Institute for Mathematical Sciences, School of Mathematical and Computer Sciences, Heriot Watt University, Edinburgh, UK. jmb7@hw.ac.uk

Bulletin of Mathematical Biology
|August 28, 2010
PubMed
Summary
This summary is machine-generated.

This study models cell differentiation, finding that spatial patterns like stripes emerge only with a strong community effect. Permanent patterns require specific cell dynamics parameters, while transient patterns can persist more broadly.

More Related Videos

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
06:49

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay

Published on: January 12, 2022

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces
12:04

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces

Published on: March 1, 2017

Related Experiment Videos

Last Updated: Jun 9, 2026

In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads
07:52

In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads

Published on: November 26, 2019

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
06:49

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay

Published on: January 12, 2022

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces
12:04

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces

Published on: March 1, 2017

Area of Science:

  • Mathematical Biology
  • Computational Biology
  • Cellular Dynamics

Background:

  • Cell differentiation is crucial for development and tissue homeostasis.
  • The local cellular environment significantly influences cell fate decisions.
  • Understanding pattern formation in cell populations is key to developmental biology.

Purpose of the Study:

  • To develop and analyze a continuous integro-differential model for two-population cell differentiation.
  • To investigate how different modes of differentiation (cell autonomous, community effect, weak environmental dependence) impact spatial pattern formation.
  • To determine the conditions necessary for the emergence of stable spatial patterns like stripes and spots.

Main Methods:

  • Formulation of a two-population continuous integro-differential model.
  • Inclusion of a non-local term to represent environmental influence on differentiation.
  • Analysis of model behavior under varying differentiation regulation mechanisms.
  • Investigation of spatial pattern formation (stripes and spots) through simulations and theoretical analysis.

Main Results:

  • Pattern formation, specifically stripes and spots, is contingent upon a strong community effect regulating differentiation.
  • Stable, permanent spatial patterns necessitate a precise relationship between cell dynamics parameters.
  • Transient spatial patterns can persist for biologically relevant durations even when parameter conditions are relaxed.
  • Observed long-lived patterns exclusively consist of stripes, with no spot formation.

Conclusions:

  • A strong community effect is essential for generating spatial patterns in cell differentiation.
  • Precise parameter tuning is required for stable, long-term pattern formation, but transient patterns offer biological relevance.
  • The model predicts stripe formation as the dominant long-lived spatial pattern, excluding spots.