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Updated: Jun 9, 2026

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay
Published on: June 16, 2021
Cyclooxygenase-2 network as predictive molecular marker for clinical pregnancy in in vitro fertilization
Inge Van Vaerenbergh1, Christophe Blockeel, Leentje Van Lommel
1Department of Pathology, Vrije Universiteit Brussel and UZ Brussel, Jette, Belgium. ivvaeren@vub.ac.be
Abstract:
The gene expression of human endometrium on the day of oocyte retrieval of pregnant and nonpregnant patients in a stimulated IVF cycle was compared in two independent groups with different GnRH-antagonist ovarian stimulation protocols. The present data suggest that increased gene expression of cyclooxygenase-2, together with the expression of other molecules in the cyclooxygenase-2 network, on the day of oocyte retrieval in GnRH-antagonist cycles coincides with a lower probability of achieving a clinical pregnancy in this cycle.
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