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Platform technologies for tubular organ regeneration
1Bioprocess Research and Assay Development, Tengion Inc., 3929 Westpoint Blvd., Suite G, Winston-Salem, NC 27103, USA. joydeep.basu@tengion.com
Trends in Biotechnology
|August 31, 2010
Summary
Regenerative medicine uses biodegradable scaffolds with smooth muscle cells to engineer tubular organs. This approach, highlighted by bladder regeneration, is advancing organ repair from concept to commercial use.
Area of Science:
- Regenerative Medicine
- Biomaterials Engineering
- Tissue Engineering
Background:
- Recent successes in engineering tubular organs reveal common methodologies.
- Biodegradable scaffolds seeded with smooth muscle cells are a key component.
- These composites initiate regeneration and de novo organogenesis in vivo.
Purpose of the Study:
- To review bladder regeneration as a model for tubular organ engineering.
- To identify universal principles applicable to regenerating various tubular organs.
- To explore the transition of tubular organ regeneration from research to commercialization.
Main Methods:
- Review of existing literature on tubular organ regeneration.
- Focus on bladder regeneration as a foundational platform.
- Analysis of common themes and principles across gastrointestinal, vascular, pulmonary, and genitourinary systems.
Main Results:
- Common principles in tubular organ regeneration have emerged.
- Bladder regeneration serves as a successful platform technology.
- These principles are applicable to diverse organ systems.
Conclusions:
- The foundational principles of tubular organ regeneration are transferable across multiple organ systems.
- The transition towards commercial viability is facilitated by understanding these common elements.
- Regenerative medicine holds significant promise for clinical applications in organ repair.
