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Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used.

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Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
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Differential spectral phase interferometry for wide dynamic range surface plasmon resonance biosensing.

Siu-Pang Ng1, Chi-Man Lawrence Wu, Shu-Yuen Wu

  • 1Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, PR China.

Biosensors & Bioelectronics
|August 31, 2010
PubMed
Summary

This study presents a new phase-sensitive surface plasmon resonance (SPR) biosensor. The novel differential spectral interferometry system achieves ultra-high sensitivity for detecting refractive index changes and biomolecular binding events.

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Area of Science:

  • Optoelectronics
  • Biosensing
  • Nanotechnology

Background:

  • Conventional surface plasmon resonance (SPR) spectroscopy monitors only the SPR dip.
  • This limits sensitivity and dynamic range in biosensing applications.
  • There is a need for more sensitive and robust SPR biosensing techniques.

Purpose of the Study:

  • To introduce a novel wide dynamic range phase-sensitive SPR biosensor.
  • To leverage differential spectral interferometry for enhanced detection.
  • To demonstrate ultra-high sensitivity and performance in biomolecular detection.

Main Methods:

  • Utilizing differential spectral interferometry to acquire full spectral phase information.
  • Employing a phase-sensitive detection approach for enhanced sensitivity.
  • Testing the biosensor with standard single-layer gold surfaces and bovine serum albumin (BSA) antibody-antigen binding.

Main Results:

  • Achieved a detection limit of 2.2×10(-7) refractive index units (RIU).
  • Demonstrated continuous sensitivity across the spectral domain.
  • Estimated a detection sensitivity of 0.5 ng ml(-1) for BSA antibody-antigen binding.

Conclusions:

  • The developed phase-sensitive SPR biosensor offers superior sensitivity and a wide dynamic range.
  • Differential spectral interferometry significantly enhances SPR biosensing capabilities.
  • The system shows great promise for sensitive and precise biomolecular detection.