Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harms Reporting Was Frequently Incomplete or Discordant in Biomedical Randomized Trials Published in 2023: A Meta-epidemiological Study.

Journal of clinical epidemiology·2026
Same author

Treating Obesity With Pharmacotherapy: Making Sense of the Evolving Science When Data Are Vast but Direct Comparative Evidence Is Sparse.

Annals of internal medicine·2026
Same author

Psychosocial Interventions for Patients Undergoing Gastrointestinal Cancer Surgery: A Systematic Review.

Annals of surgical oncology·2026
Same author

Influence of Social and Demographic Factors on Retinoblastoma Outcomes in the United States: A Systematic Review.

Cochrane evidence synthesis and methods·2026
Same author

Dynamic lattice disorder overrides energetics for barrierless interfacial charge transfer in 2D hybrid perovskites.

Science advances·2026
Same author

A Systematic Review of Patient-Reported Outcome Instruments Relevant to Glaucoma.

Journal of glaucoma·2026
Same journal

Diverse Conjunctival Adverse Events Associated with Tisotumab Vedotin.

Ophthalmology·2026
Same journal

The Answer Is Blowing in the Wind: Uncovering Hidden Glaucoma Risk Factors.

Ophthalmology·2026
Same journal

Nonsteroidal Anti-inflammatory Drug Use Reduces the Risk of Age-Related Macular Degeneration in Electronic Health Record Analysis: Signal or Solution?

Ophthalmology·2026
Same journal

Metastasis of Nasopharyngeal Squamous Cell Carcinoma to the Angle.

Ophthalmology·2026
Same journal

Endocrine Mucin-Producing Sweat Gland Carcinoma of Eyelid.

Ophthalmology·2026
Same journal

Multimodal Imaging of Optic Nerve Invasion in Unilateral Retinoblastoma.

Ophthalmology·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Setting priorities for comparative effectiveness research: a case study using primary open-angle glaucoma.

Tianjing Li1, Ann-Margret Ervin, Roberta Scherer

  • 1Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. tli@jhsph.edu

Ophthalmology
|August 31, 2010
PubMed
Summary
This summary is machine-generated.

A new framework effectively prioritized comparative effectiveness research questions for primary open-angle glaucoma management. This approach, using practice guidelines and clinician surveys, proved feasible and pragmatic for future research prioritization.

Related Experiment Videos

Last Updated: Jun 9, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Area of Science:

  • Ophthalmology
  • Health Services Research
  • Clinical Research Prioritization

Background:

  • Primary open-angle glaucoma (POAG) management requires ongoing research to optimize patient outcomes.
  • Existing practice guidelines may not fully address emerging clinical questions.
  • Comparative Effectiveness Research (CER) is crucial for evidence-based decision-making.

Purpose of the Study:

  • To assess the feasibility of a novel framework for prioritizing CER questions in POAG management.
  • To utilize practice guidelines and clinician input for research prioritization.

Main Methods:

  • A cross-sectional survey design was employed.
  • Recommendations from the American Academy of Ophthalmology Preferred Practice Patterns (PPPs) for POAG were transformed into clinical questions.
  • A 2-round Delphi survey of American Glaucoma Society (AGS) members was conducted online to rank question importance.

Main Results:

  • Forty-five clinical questions were generated from the POAG PPPs.
  • A total of 169 AGS members completed Round 1 and 105 completed Round 2 of the survey.
  • Nine clinical questions were identified as highest priority, focusing on medical interventions, filtering surgery, and therapy adjustment.

Conclusions:

  • The developed theoretical model for prioritizing CER questions is a feasible and pragmatic method.
  • This approach demonstrates potential for application in other medical fields for research prioritization.