A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ
Tsuyoshi Saitoh1, Chika Shimada, Masatoshi Takeiri
1Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.
Bioorganic & Medicinal Chemistry Letters
|August 31, 2010
Abstract:
The amino-epoxyquinols 6a and 6b were synthesized as soluble derivatives of an NF-κB inhibitor DHMEQ (1). In spite of the opposite configuration from 1, 6b rather than 6a affected the deactivation of NF-κB, based on NO secretion and MALDI-TOF MS analysis. It was indicated that 6b inhibited the activation by different manner from that of 1.


