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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Array-based sensing with nanoparticles: 'chemical noses' for sensing biomolecules and cell surfaces
Oscar R Miranda1, Brian Creran, Vincent M Rotello
1Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Current Opinion in Chemical Biology
|August 31, 2010
Summary
New nanoparticle
Area of Science:
- Biomolecular detection
- Nanotechnology
- Chemical sensing
Background:
- Nanoparticle arrays enable pattern recognition for biomolecular target identification.
- Existing methods require sensitive detection systems for various bioanalytes.
Purpose of the Study:
- To present novel 'chemical nose' methodologies utilizing nanoparticle systems.
- To demonstrate high-sensitivity sensing of diverse biomolecular targets.
Main Methods:
- Development of fluorescent polymer/gold nanoparticle complexes.
- Utilization of dye-based micellar systems.
- Application of pattern recognition for bioanalyte discrimination.
Main Results:
- Demonstrated discrimination between proteins, bacteria, and mammalian cells using nanoparticle complexes.
- Achieved sensitive detection of clinically relevant metalloproteins and nonmetalloproteins with micellar systems.
Conclusions:
- Nanoparticle-based 'chemical nose' systems offer high sensitivity and specificity for biomolecular detection.
- These methodologies show promise for identifying a wide range of clinically significant bioanalytes.
