Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Classification of Illness01:17

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional patterns of grey matter volume decline in relapsing-remitting multiple sclerosis relative to healthy ageing.

NeuroImage·2026
Same author

Rituximab versus Ocrelizumab in Newly Diagnosed Relapsing Multiple Sclerosis.

The New England journal of medicine·2026
Same author

Alpha-linolenic acid associations with disability and brain volume in multiple sclerosis: a brief replication report.

Frontiers in neurology·2026
Same author

Low risk of severe COVID-19 in vaccinated people with multiple sclerosis: a nationwide Norwegian study.

BMJ neurology open·2026
Same author

Distinct Prescription Patterns Emerge Years Before ALS Diagnosis: A Nationwide Registry-Based Study.

Annals of neurology·2026
Same author

NorTrials drives growth in Norwegian clinical trials.

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2026

Related Experiment Video

Updated: Jun 9, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

How long can you keep working with benign multiple sclerosis?

Solveig B Glad1, Harald Nyland, Jan Harald Aarseth

  • 1The Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway. solveig.bergliot.glad@helse-bergen.no

Journal of Neurology, Neurosurgery, and Psychiatry
|August 31, 2010
PubMed
Summary

Employment in multiple sclerosis (MS) is influenced by disease course and work type. Mild depressive symptoms significantly impact employment in benign MS patients, highlighting the need for mental health support.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Related Experiment Videos

Last Updated: Jun 9, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Neurology
  • Occupational Health
  • Epidemiology

Background:

  • Multiple sclerosis (MS) significantly impacts employment and quality of life.
  • Understanding factors affecting employment in benign MS is crucial for patient support.

Purpose of the Study:

  • To analyze employment rates in a benign multiple sclerosis (MS) cohort.
  • To identify early clinical and demographic factors influencing time to disability pension.
  • To compare employment-related factors between benign and non-benign MS patients.

Main Methods:

  • A population-based cohort of 188 MS patients (onset 1976-1986) was assessed in 2003.
  • Data collected included Expanded Disability Status Scale (EDSS), depression, cognitive function, fatigue, pain, and employment status.
  • Benign MS was defined as EDSS ≤3.0 at least 10 years post-onset.

Main Results:

  • After a mean of 22.2 years, 32.4% of the MS cohort remained employed.
  • Relapsing-remitting course, higher education, and light work predicted longer employment duration in the general MS population.
  • Among benign MS patients (n=60), 65% were employed; mild depressive symptoms were strongly associated with non-employment (OR=7.3).

Conclusions:

  • Disease course, education, and work type are key predictors of employment duration in MS.
  • Depressive symptoms, even mild, significantly hinder employment in benign MS patients.
  • Targeted interventions for mental health may improve employment outcomes in benign MS.