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Pandemic influenza a (2009 H1N1) in human immunodeficiency virus-infected catalan children

Antoni Noguera-Julian1, Ana C Provens, Pere Soler-Palacín

  • 1Infectious Diseases Unit, Department of Pediatrics, Hospital Universitari Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain. ton@hsjdbcn.org

The Pediatric Infectious Disease Journal
|August 31, 2010
PubMed

Insights

Pandemic influenza (H1N1) in children with human immunodeficiency virus (HIV) showed mild symptoms, with most treated as outpatients. The infection did not negatively impact HIV progression in this vulnerable group.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Immunology

Background:

  • Limited data exist on 2009 H1N1 influenza in pediatric populations with human immunodeficiency virus (HIV).
  • HIV-infected children represent a vulnerable group susceptible to severe outcomes from novel influenza strains.

Purpose of the Study:

  • To describe the clinical presentation and outcomes of pandemic H1N1 influenza in a cohort of HIV-infected children.
  • To assess the impact of H1N1 influenza on the progression of HIV infection in pediatric patients.

Main Methods:

  • Retrospective case series analysis of 13 HIV-infected children diagnosed with H1N1 influenza.
  • Review of clinical features, treatment (including antiviral use), hospitalization, and HIV disease evolution.

Main Results:

  • Clinical manifestations of H1N1 influenza in HIV-infected children mirrored those in the general population.
  • Most cases were managed with outpatient antiviral therapy, with only 2 requiring hospitalization.
  • Influenza infection did not adversely affect the course of HIV infection.

Conclusions:

  • 2009 H1N1 influenza appears to have an uneventful clinical course in most HIV-infected children.
  • Antiviral treatment is effective in managing H1N1 influenza in this cohort.
  • Pandemic influenza does not seem to alter HIV disease progression in pediatric patients.

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