Related Experiment Videos
Gout and coexisting pseudogout in the knee joint
Yonsik Yoo1, Young-Jin Seo, Mina Huh
1Center for Arthroscopy, Department of Orthopaedic Surgery, Hallym University Hangang Sacred Heart Hospital, 94-200 Youngdeungpo-Dong, Youngdeungpo-Ku, 150-719, Seoul, Korea.
Summary
This case study found both gout (monosodium urate crystals) and pseudogout (calcium pyrophosphate dihydrate crystals) in the same knee joint. Compensated polarized microscopy is key for diagnosing crystal-induced arthritis.
Area of Science:
- Rheumatology
- Crystallography
- Orthopedics
Background:
- Gout and pseudogout are common crystal-induced arthropathies.
- Typically, these conditions affect different joints or occur independently.
Observation:
- A 63-year-old male presented with simultaneous gout and pseudogout in the same knee joint.
- Clinical features and synovial fluid analysis were performed.
Findings:
- Compensated polarized microscopy confirmed the presence of both monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals in the affected knee joint.
- This is an unusual presentation of crystal deposition disease.
Implications:
- The coexistence of gout and pseudogout should be considered in diagnosing crystal-induced arthritis.
- Utilizing compensated polarized microscopy is crucial for identifying mixed crystal depositions in joints.
- This case highlights the importance of thorough crystal analysis for accurate diagnosis and management.
Related Concept Videos
Knee Joint
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
Bones of the Lower Limb: Femur and Patella
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the neck...
Ankle Joint
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...