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Related Experiment Videos

[Relationship between aging and renal function: a positron emission tomographic study].

M Yamashita1, T Inaba, Y Oda

  • 1Kyoto Prefectural University of Medicine.

Radioisotopes
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Kidney blood volume, blood flow, and glomerular filtration rate decrease with age. By age 70, these functions are significantly reduced compared to those in their 20s.

Area of Science:

  • Nephrology
  • Gerontology
  • Nuclear Medicine

Background:

  • Aging is associated with physiological changes in organ function.
  • Kidney function, including blood flow and filtration, may decline with age.
  • Quantifying age-related changes in kidney hemodynamics is crucial for understanding renal health.

Purpose of the Study:

  • To investigate age-related changes in kidney blood volume, blood flow, and glomerular filtration rate per unit of kidney tissue.
  • To quantify the decline in these parameters in older adults compared to younger individuals.

Main Methods:

  • Utilized positron emission tomography (PET) with C15O, H(2)15O, and 68Ga-EDTA to measure kidney blood volume (V), blood flow (F), and glomerular filtration rate (GFR).
  • Studied 19 subjects across different age groups.

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  • Applied regression analysis to determine age-related trends.

    • Main Results:

    • A significant negative correlation was observed between age and kidney blood volume, blood flow, and GFR.
    • The decrease in kidney blood volume with aging was less pronounced than the decrease in blood flow and GFR.
    • Regression analysis indicated that by the 70s, kidney blood flow, GFR were reduced to 76%, 46%, and 55% of levels seen in the 20s, respectively.

    Conclusions:

    • Kidney blood volume, blood flow, and glomerular filtration rate demonstrably decline with age.
    • These findings highlight significant age-related functional decrements in the kidney, particularly in blood flow and filtration capacity.