[Anti-inflammatory role of cholinergic and serotonergic systems in shock]

Development of anaphylactic shock initiated with the horse serum (anaphylactic index = 4.0 +/- 0.0 arbitrary units) leads to acute decrease in spleen concentration of serotonin (in shock--0.443 +/- 0.005; basal level--1.532 +/- 0.004 ng per mg of protein). Unlike of anaphylaxis, development of endotoxic shock in rats, caused by introduction of a sublethal dose (20 mg/kg) of lipopolysaccharide, results in acute increase in serotonin concentration (at a shock--56.588 +/- 0.006, basal level--5.465 +/- 0.005 ng per mg of protein) and marked tachycardia (+76 +/- 8, intact rats--+2 +/- 1 beats per min). Administration of atropine with galantamine leads to the most essential decrease of anaphylactic reaction (1.5 +/- 0.3 arbitrary units). Administration of choline alfoscerate (-16 +/- 3 beats per min) or galantamine (+9 +/- 2 beats per min) significantly reduces tachycardia. Data show, that inhibition of the central cholinergic mechanisms leads to increase and their excitation--to decrease in activity of the spleen serotonergic system. So, spleen concentration of serotonin is connected with a target of shock defeat (lungs or heart).