Related Experiment Video
Updated: Jun 9, 2026

Isolating Primary Melanocyte-like Cells from the Mouse Heart
Published on: September 29, 2014
Erythropoietin is involved in angiogenesis in human primary melanoma
Domenico Ribatti1, Beatrice Nico, Maria Teresa Perra
1Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it
Abstract:
In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis and tumour thickness. These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis.
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Mechanism of Angiogenesis
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Mitogens and the Cell Cycle

