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Related Experiment Video

Updated: Jun 9, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

[Annular elastolytic giant-cell granuloma].

Y Le Corre1, M Steff, B Prophette

  • 1Service de dermatologie, centre hospitalier du Mans, 72000 Le-Mans, France. lecorre_y@yahoo.fr

Annales De Dermatologie Et De Venereologie
|September 1, 2010
PubMed
Summary
This summary is machine-generated.

Annular elastolytic giant-cell granuloma (AEGCG) is a rare skin condition. This case report details a patient diagnosed with AEGCG and highlights the first reported successful treatment with isotretinoin.

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Last Updated: Jun 9, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Dermatology
  • Granulomatous Dermatoses

Background:

  • Annular elastolytic giant-cell granuloma (AEGCG) is a rare granulomatous dermatosis.
  • Characterized by annular plaques with central atrophy, raised erythematous margins, typically on facial/neck areas.
  • Histological features include elastic fiber loss and elastophagocytosis.

Observation:

  • A 72-year-old man presented with annular plaques and papules of 2-year duration.
  • Lesions affected both sun-exposed and non-sun-exposed skin.
  • Biopsies revealed granulomatous infiltrates and elastophagocytosis.

Findings:

  • Diagnosis of AEGCG was confirmed after excluding other conditions like actinic granuloma, sarcoidosis, leprosy, and granuloma annulare.
  • The patient exhibited both classical annular and papular variants of AEGCG.
  • This case represents the first documented response to isotretinoin treatment for AEGCG.

Implications:

  • AEGCG diagnosis can be challenging, requiring careful exclusion of differential diagnoses.
  • The combination of annular and papular variants can occur.
  • Isotretinoin shows promise as a potential treatment for AEGCG.