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Updated: Jun 9, 2026

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
Published on: November 18, 2013
Insights into neurogenesis and aging: potential therapy for degenerative disease?
Robert A Marr1, Rosanne M Thomas, Daniel A Peterson
1Department of Neuroscience, Center for Stem Cell & Regenerative Medicine, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Abstract:
Neurogenesis is the process by which new neural cells are generated from a small population of multipotent stem cells in the adult CNS. This natural generation of new cells is limited in its regenerative capabilities and also declines with age. The use of stem cells in the treatment of neurodegenerative disease may hold great potential; however, the age-related incidence of many CNS diseases coincides with reduced neurogenesis. This review concisely summarizes current knowledge related to adult neurogenesis and its alteration with aging and examines the feasibility of using stem cell and gene therapies to combat diseases of the CNS with advancing age.
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