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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Related Experiment Video

Updated: Jun 9, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

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[Tumour stem cells and metastasis].

U F Wellner¹, U T Hopt, T Brabletz

¹Universitätsklinikum der Albert-Ludwigs-Universität, Chirurgische Klinik, Abteilung Allgemein- und Viszeralchirurgie, Freiburg, Deutschland. ulrich.wellner@uniklinikfreiburg.de

Zentralblatt Fur Chirurgie

|September 1, 2010

Summary

Cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT) are key to cancer development and metastasis. Recent research links these phenomena, offering new insights into tumor progression and spread.

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A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

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Published on: May 6, 2018

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

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Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Area of Science:

Oncology
Cancer Biology
Cellular Biology

Context:

Cancer development, invasion, and metastasis mechanisms are incompletely understood.
Cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) are implicated in these processes.
CSCs are crucial for tumor development and persistence.

Purpose:

To explore the relationship between cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT).
To understand how CSCs and EMT contribute to cancer progression and metastasis.

Summary:

The embryonic epithelial-mesenchymal transition (EMT) program is aberrantly activated in invasive cancer cells.
EMT contributes significantly to tumor invasion and the spread of cancer.
Emerging evidence indicates a close relationship between EMT traits and CSC characteristics.

Impact:

This research provides novel explanatory models for cancer development and metastasis.
Understanding the interplay between CSCs and EMT can lead to new therapeutic strategies.
Highlights the importance of CSCs and EMT in understanding and combating metastatic cancer.