Related Experiment Video
Updated: Jun 9, 2026

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System
Published on: December 10, 2021
Development of the Huntington disease family concerns and strategies survey from focus group data
Janet K Williams1, J Jackson Barnette, David Reed
1College of Nursing, University of Iowa, Iowa City, IA 52242, USA. janet-williams@uiowa.edu
Abstract:
Health concerns and management strategies among families of young and middle-age adults with Huntington's disease (HD) are unknown. This study developed and tested psychometric properties of the Huntington Disease Family Concerns and Strategies Survey (HDFCSS). Focus group data from 91 adult family members were used to develop content. Content analysis yielded four domains that were transferred into Personal, Person With HD, Community Health Care Services, and Strategies scales. Focus group data, expert validation, and cognitive interviews demonstrated survey content validity. Cronbach's alpha internal consistency coefficients for the scales were 0.83 or above. The measure can be used to generate reliable and valid data to identify adult family members' health-related concerns and management strategies for themselves and persons with HD.
Related Concept Videos
Huntington Disease l: Introduction
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Sex-linked Disorders
Longitudinal Research
Pharmacogenomics: Identification of New Drug Targets
Preclinical Development: Overview

