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Systemic involvement of dialysis-amyloidosis
J M Campistol1, M Solé, J Muñoz-Gomez
1Nephrology Service, Hospital Clinic i Provincial, University of Barcelona, Spain.
American Journal of Nephrology
|January 1, 1990
Summary
Dialysis amyloidosis, caused by beta-2-microglobulin, often affects organs beyond joints in hemodialysis patients. Echocardiography and biopsies reveal widespread visceral involvement in most symptomatic individuals.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- A novel form of amyloidosis, primarily affecting bones and joints, has been identified in patients undergoing hemodialysis.
- Beta-2-microglobulin is the main protein component of this amyloidosis.
- The extent of amyloid deposition in dialysis amyloidosis, whether localized or systemic, remains unclear.