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Updated: Jun 9, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
A novel four-component reaction for the synthesis of disubstituted 1,3,4-oxadiazole derivatives
Ali Ramazani1, Nahid Shajari, Amir Mahyari
1Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran. aliramazani@gmail.com
Abstract:
The 1:1 imine intermediate generated by the addition of benzyl amine to cyclobutanone is trapped by (N-isocyanimino)triphenylphosphorane in the presence of an aromatic carboxylic acid leads to the formation of the corresponding iminophosphorane intermediate. Disubstituted 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reactions were completed in neutral conditions at room temperature. The disubstituted 1,3,4-oxadiazole derivatives, were produced in excellent yields.
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