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Updated: Jun 9, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
New antifungal steroids from Turbinaria conoides (J. Agardh) Kutzing
S Sadish Kumar1, Y Kumar, M S Y Khan
1Department of Pharmaceutical Chemistry, I.T.S. Paramedical College, Ghaziabad, Uttar Pradesh, India. jesisjes@yahoo.co.in
Abstract:
Two new steroids 3,6,17-trihydroxy-stigmasta-4,7,24(28)-triene (1) and 14,15,18,20-diepoxyturbinarin (3), together with a known compound, fucosterol (2), were isolated from the cyclohexane extract of Turbinaria conoides. The structures were elucidated on the basis of spectroscopic evidence. The isolated compounds were screened against a panel of microorganisms. Minimum inhibitory concentrations (MICs) were determined by the standard broth dilution method. Compounds 1-3 exhibited moderate antibacterial activity against the tested bacteria and inhibited the fungal growth with MIC values ranging from 2 to 16 microg mL(-1). Compound 3 was found to be most potent against Aspergillus niger, with an MIC value of 2.0 microg mL(-1). The isolation of antifungal compounds from T. conoides is reported for the first time. These results suggested that 14,15,18,20-diepoxyturbinarin (3) could be developed as a new lead antifungal agent.
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